Ipatimup

Marina Leite

Name: Marina Leite

E-mail: mleite@ipatimup.pt

Marina Leite

Short CV

Marina Leite obtained her degree in Biology in 1991 at the Faculty of Sciences of the University of Porto. Then, in 1996 she got a master degree in Oncobiology at Faculty of Medicine of the University of Porto (FMUP) and at the Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), and in 2006 a PhD on Human Biology also at FMUP/Ipatimup. During her PhD, Marina Leite was trained at the José Eduardo Guimarães laboratory at Ipatimup, and abroad at the João Ascensão/Esmail Zanjani laboratory at the Veterans Affairs Medical Center, Reno, USA, and at the Angelo A. Cardoso/Lee Nadler laboratory at Dana-Farber Cancer Institute, Boston, USA. Currently, Marina Leite holds a post-doctoral position at the Ipatimup, and is author/co-author of 11 papers in peer-reviewed international journals and 3 book chapters.

Highlights

Marina Leite main research interests are: to understand the interactions between the Helicobacter pylori and gastric epithelial cells that contribute to disease development; to identify new H. pylori virulence factors and its mechanisms of action; and, to identify new host targets of H. pylori infection, its signaling pathways and cellular functions that are disturbed by the bacteria.

Supervisor of

Inês Feliciano, Research Trainee

PI (closed)

Urease de helicobacter pylori: propriedades não relacionadas com a actividade enzimática que potencialmente contribuem para gastrite e cancro gástrico

Urease de helicobacter pylori: propriedades não enzimáticas que potencialmente contribuem para gastrite e cancro gástrico

First Author

1. Leite M, Marques MS, Melo J, Pinto MT, Cavadas B, Aroso M, Gomez-Lazaro M, Seruca R, Figueiredo C

Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions. Cells 9: ., 2020. [Article]

doi: 10.3390/cells9020513 PMID: 32102381.

4.4 (*)

2. Ferreira RM, Machado JC, Leite M, Carneiro F, Figueiredo C

The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma. Histopathology 60: 992-8, 2012. [Article]

doi: 10.1111/j.1365-2559.2012.04190.x PMID: 22348604.

2.9

3. Leite M, Figueiredo C

A method for short-term culture of human gastric epithelial cells to study the effects of Helicobacter pylori. Methods in molecular biology (Clifton, N.J.) 921: 61-8, 2012. []

doi: 10.1007/978-1-62703-005-2_9 PMID: 23015492.

4. Leite M, Corso G, Sousa S, Milanezi F, Afonso LP, Henrique R, Soares JM, Castedo S, Carneiro F, Roviello F, Oliveira C, Seruca R

MSI phenotype and MMR alterations in familial and sporadic gastric cancer. International journal of cancer 128: 1606-13, 2011. [Article]

doi: 10.1002/ijc.25495 PMID: 20533283.

5.4

5. Leite M, Quinta-Costa M, Leite PS, Guimarães JE

Critical evaluation of techniques to detect and measure cell death--study in a model of UV radiation of the leukaemic cell line HL60. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 19: 139-51, 1999. [Article]

PMID: 10866276.

159

Senior Author

1. Melo J, Pinto V, Fernandes T, Malheiro AR, Osório H, Figueiredo C, Leite M

Isolation Method and Characterization of Outer Membranes Vesicles of Helicobacter pylori Grown in a Chemically Defined Medium. Frontiers in microbiology 12: 654193, 2021. [Article]

doi: 10.3389/fmicb.2021.654193 PMID: 34149641.

5.6 (*)

2. Marques MS, Melo J, Cavadas B, Mendes N, Pereira L, Carneiro F, Figueiredo C, Leite M

Afadin Downregulation by Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Gastric Cells. Frontiers in microbiology 9: 2712, 2018. [Article]

doi: 10.3389/fmicb.2018.02712 PMID: 30473688.

4.0 (*)

@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto