Ipatimup

RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH

João Vinagre

Name: João Vinagre

E-mail: jvinagre@i3s.up.pt

João Vinagre

Member of

Assistant Researcher of Cancer Signalling & Metabolism

Consultant of Ipatimup Diagnostics

Short CV

Faculty of Biotechnology – Portuguese Catholic University
Degree in Microbiology, 2006
PhD student: Programa Doutoral Ciências Veterinárias – Instituto Ciências Biomedicas Abel Salazar

Pópulo H, Vinagre J, Lopes JM, Soares P: ""Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas"". British Journal of Ophthalmology 2011 May;95(5):715-9; Epub 2010 Aug 30.

Eloy C, Vinagre J, Cameselle-Teijeiro J, Paiva ME, Soares P, Sobrinho-Simões M. : ""Tumor-in-Tumor of the Thyroid With Basaloid Differentiation: A Lesion With a Solid Cell Nest Neoplastic Component?"" Int J Surg Pathol. 2011 Apr;19(2):276-80.

Cruz J, Eloy C, Aragüés JM, Vinagre J, Sobrinho-Simões M.: “Small cell (basaloid) thyroid carcinoma – A neoplasm with a solid cell nest histogenesis?”. International Journal of Surgical Pathology. 2011 Apr 28.

Alvarenga CA, Lopes JM, Vinagre J, Paravidino PI, Alvarenga M, Prando A, Castilho LN, Soares P, Billis A:Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review. São Paulo Medical Journal 2012;130(1):57-60.

Celestino R, Lima J, Faustino A, Máximo V, Gouveia A, Vinagre J, Soares P, Lopes JM.: ""A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney-Stratakis dyad."" Fam Cancer. 2012 Jun;11(2):189-94.

Celestino R, Lima J, Faustino A, Vinagre J, Máximo V, Gouveia A, Soares P, Manuel Lopes J. Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors. Eur J Hum Genet. 2012 Sep 5. doi: 1038/ejhg.2012.205. [Epub ahead of print]

Alvelos MI, Vinagre J, Fonseca E, Barbosa E, Teixeira-Gomes J, Sobrinho-Simões M, Soares P. MEN1 intragenic deletions may represent the most prevalent somatic event in sporadic primary hyperparathyroidism. Eur J Endocrinol. 2012 Oct 23. [Epub ahead of print]

Highlights

Neuroendocrine tumors oncobiology. Thyroid pathology.

Supervisor of

Raquel Borges, Master Student (thesis)
MSc student

Beatriz Silva, Master Student (theoretical phase)
MSc student

Gabriela Silva, Master Student (theoretical phase)
MSc student

Isabel Almeida, Research Trainee
Research Trainee

Lia Rodrigues, PhD Student
PhD student

Mafalda Gonçalves, Junior Researcher
Junior Researcher

First Author

1. Vinagre J, Pinheiro J, Martinho O, Reis RM, Preto J, Soares P, Lopes JM

A 30-Year Long-Term Experience in Appendix Neuroendocrine Neoplasms-Granting a Positive Outcome. Cancers 12: ., 2020. [Article]

doi: 10.3390/cancers12061357 PMID: 32466539.

6.1 (*)

2. Vinagre J, Nabais J, Pinheiro J, Batista R, Oliveira RC, Gonçalves AP, Pestana A, Reis M, Mesquita B, Pinto V, Lyra J, Cipriano MA, Ferreira MG, Lopes JM, Sobrinho-Simões M, Soares P

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes. Scientific reports 6: 29714, 2016. [Article]

doi: 10.1038/srep29714 PMID: 27411289.

4.3

3. Vinagre J, Pinto V, Celestino R, Reis M, Pópulo H, Boaventura P, Melo M, Catarino T, Lima J, Lopes JM, Máximo V, Sobrinho-Simões M, Soares P

Telomerase promoter mutations in cancer: an emerging molecular biomarker? Virchows Archiv : an international journal of pathology 465: 119-33, 2014. [Review]

doi: 10.1007/s00428-014-1608-4 PMID: 25048572.

2.7

4. Vinagre J, Almeida A, Pópulo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R, Prazeres H, Lima L, Melo M, Rocha AG, Preto A, Castro P, Castro L, Pardal F, Lopes JM, Santos LL, Reis RM, Cameselle-Teijeiro J, Sobrinho-Simões M, Lima J, Máximo V, Soares P

Frequency of TERT promoter mutations in human cancers. Nature communications 4: 2185, 2013. [Article]

doi: 10.1038/ncomms3185 PMID: 23887589.

649

10.7

5. Celestino R, Lima J, Faustino A, Máximo V, Gouveia A, Vinagre J, Soares P, Lopes JM

A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney-Stratakis dyad. Familial cancer 11: 189-94, 2012. [Article]

doi: 10.1007/s10689-011-9499-x PMID: 22160509.

1.9

Senior Author

1. Gaspar TB, Macedo S, Sá A, Soares MA, Rodrigues DF, Sousa M, Mendes N, Martins RS, Cardoso L, Borges I, Canberk S, Gärtner F, Miranda-Alves L, Sobrinho-Simões M, Lopes JM, Soares P, Vinagre J

Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour. Cancers 14: ., 2022. [Article]

doi: 10.3390/cancers14163865 PMID: 36010860.

6.6 (*)

2. Gaspar TB, Lopes JM, Soares P, Vinagre J

An update on genetically engineered mouse models of pancreatic neuroendocrine neoplasms. Endocrine-related cancer 29: R191-R208, 2022. [Review]

doi: 10.1530/ERC-22-0166 PMID: 36197786.

3. Rodrigues L, Canberk S, Macedo S, Soares P, Vinagre J

DGCR8 Microprocessor Subunit Mutation and Expression Deregulation in Thyroid Lesions. International journal of molecular sciences 23: ., 2022. [Article]

doi: 10.3390/ijms232314812 PMID: 36499151.

6.2 (*)

4. Gaspar TB, Pinheiro J, Canberk S, Ince U, Tokat F, Lopes JM, Maximo V, Soares P, Vinagre J

Characterization of 142 Human Pancreatic Neuroendocrine Tumors: ATRX and DAXX Correlation with Clinical-Pathological Data Neuroendocrinology 110: 9-9, 2020. [Meeting Abstract]

4.3 (*)

5. Gaspar TB, Sá A, Lopes JM, Sobrinho-Simões M, Soares P, Vinagre J

Telomere Maintenance Mechanisms in Cancer. Genes 9: ., 2018. [Review]

doi: 10.3390/genes9050241 PMID: 29751586.

3.2 (*)

6. Batista R, Gaspar TB, Soares P, Vinagre J

Editorial on "The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma" TRANSLATIONAL CANCER RESEARCH 7: S762-S765, 2018. [Editorial Material]

doi: 10.21037/tcr.2018.08.06.

1.2 (*)

@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto