RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH
 
Céu Figueiredo
Name: Céu Figueiredo
E-mail: cfigueiredo@ipatimup.pt
Extension: 
225570700
Academic Degree: PhD


Céu Figueiredo
Céu Figueiredo
Member of
Consultant of Ipatimup Diagnostics
Researcher of Microbes & Cancer


Short CV

Ceu Figueiredo, PhD, is a Group Leader at i3S/Ipatimup and an Associate Professor at the Department of Pathology at the Faculty of Medicine of the University of Porto. Her research has been dedicated to studying the pathogenesis of Helicobacter pylori infection, namely the epidemiology and clinical relevance of H. pylori virulence factors, and the interaction between bacterial virulence factors and human genetic susceptibility to gastric carcinoma. She is investigating the role of H. pylori virulence factors in the outcome of the infection, using clinical specimens and patient cohorts; and the role of H. pylori in epithelial cell responses and underlying signaling pathways relevant to gastric carcinoma development, using in vitro models and validation in clinical specimens. More recently, she has been studying the human gastric microbiota using next-generation sequencing of samples from the stomach of patients with different lesions. As of May 2024, she has published over 130 peer-reviewed papers and 10 book chapters, and has two international patents. She has an h-index of 47 and her work has been cited more than 7.950 times.  She has coordinated and participated in several major research projects, including national projects funded by the Foundation for Science and Technology (FCT), Agency for Innovation, Ministry of Health, and Gulbenkian Foundation, and in international projects funded by the European Commission (FP6, H2020, and Horizon Europe), ERA-NET Pathogenomics, and the Worldwide Cancer Research.

 

Highlights
Ceu Figueiredo’s research has been dedicated to studying the pathogenesis of Helicobacter pylori infection, namely the epidemiology and clinical relevance of H. pylori virulence factors, and the interaction between bacterial virulence factors and human genetic susceptibility to gastric carcinoma. She is investigating the role of H. pylori virulence factors in the outcome of the infection, using clinical specimens and patient cohorts; and the role of H. pylori in epithelial cell responses and underlying signaling pathways relevant to gastric carcinoma development, using in vitro models and validation in clinical specimens. More recently, she has been studying the human gastric microbiota using next-generation sequencing of samples from the stomach of patients with different lesions.

Supervisor of
Inês Castro, Master Student (theoretical phase)
MSc student
Joana Marques, Junior Researcher
Visiting Researcher
Joana Oliveira, PhD Student
PhD student
João Santos, Visiting Researcher
Visiting Researcher
Maria Tavares, PhD Student
PhD student
Melissa Rocha, PhD Student
PhD student
Patrícia Vieira, PhD Student
PhD student
Sónia Miranda, PhD Student
PhD student

PI (running)
Helicobacter pylori sensitivity to clarithromycin in Fiji using genetic testing of paraffin fixed biopsy specimens

PI (closed)
CeLac and European consortium for a personalized medicine approach to Gastric Cancer
Helicophage - desenvolvimento de um cocktail de fagos modificados para combater infecções provocadas por Helicobacter pylori e para prevenir o cancro gástrico
Development of NAM-CLASI-FIVH method: a new in vivo tool for an accurate analysis of diversity and spatial organization of gastric microbiota
Helicobacter pylori factors and host cell signaling pathways in gastric cancer cell adhesion and invasion.
Gastric Microbiota & Cancer: More than Helicobacter Pylori
Helicobacter pylori genetic variation: An opportunity to identify individuals at increased risk for disease
Unravelling a new Helicobacter pylori virulence factor involved in tight junction dysfunction
HeliSysBio - Molecular Systems Biology Helicobacter pylori
Cooperação Científica e Tecnológica
Global RNAi approaches to unravel eukaryotic host functions that modulate bacterial infections
Avaliação do risco do consumo de sal e da infecção por Helicobacter pylori no desenvolvimento de carcinoma gástrico e das suas lesões precursoras em Portugal
Caracterização de nove membros da familia das proteínas externas de membrana em estirpes de Helicobacter pylori isoladas de doentes Portugueses
Effects of Helicobacter pylori on gastric epithelial cells
Gene Environment interactions in human carcinogenesis with emphasis on gastric cancer
Helicobacter Pylori: da Biologia à clínica
First Author
 
C
IF
1. Figueiredo C, Camargo MC, Leite M, Fuentes-Pananá EM, Rabkin CS, Machado JC
Pathogenesis of Gastric Cancer: Genetics and Molecular Classification. Current topics in microbiology and immunology 400: 277-304, 2017. [Review; Book Chapter] 
 doi: 10.1007/978-3-319-50520-6_12 PMID: 28124158.
 
92
5.8
2. Figueiredo C, Camargo MC, Leite M, Fuentes-Pananá EM, Rabkin CS, Machado JC
Erratum to: Pathogenesis of Gastric Cancer: Genetics and Molecular Classification. Current topics in microbiology and immunology 400: E1, 2017. [Correction; Book Chapter] 
 doi: 10.1007/978-3-319-50520-6_15 PMID: 28608027.
 
3
5.8
3. Figueiredo C, Costa S, Karameris A, Machado JC
Pathogenesis of Gastric Cancer. Helicobacter 20 Suppl 1: 30-5, 2015. [Article] 
 doi: 10.1111/hel.12254 PMID: 26372822.
 
31
3.9
4. Figueiredo C, Garcia-Gonzalez MA, Machado JC
Molecular pathogenesis of gastric cancer. Helicobacter 18 Suppl 1: 28-33, 2013. [Review] 
 doi: 10.1111/hel.12083 PMID: 24011242.
 
59
3.0
5. Figueiredo C, Machado JC, Yamaoka Y
Pathogenesis of Helicobacter pylori Infection. Helicobacter 10 Suppl 1: 14-20, 2005. [Article] 
 doi: 10.1111/j.1523-5378.2005.00339.x PMID: 16178966.
 
53
2.6
6. Figueiredo C, Machado JC
Re: Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma Journal of the National Cancer Institute 95: 760-761, 2003. [Letter] 
.
 
0
13.8
7. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-Simões M
Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. Journal of the National Cancer Institute 94: 1680-7, 2002. [Article] 
 PMID: 12441323.
 
489
14.5
8. Figueiredo C, Van Doorn LJ, Nogueira C, Soares JM, Pinho C, Figueira P, Quint WG, Carneiro F
Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains. Scandinavian journal of gastroenterology 36: 128-35, 2001. [Article] 
 PMID: 11252403.
 
105
1.8
9. Figueiredo C, Quint W, Nouhan N, van den Munckhof H, Herbrink P, Scherpenisse J, de Boer W, Schneeberger P, Perez-Perez G, Blaser MJ, van Doorn LJ
Assessment of Helicobacter pylori vacA and cagA genotypes and host serological response. Journal of clinical microbiology 39: 1339-44, 2001. [Article] 
 doi: 10.1128/JCM.39.4.1339-1344.2001 PMID: 11283053.
 
38
4.0
10. Figueiredo C
Molecular and Cellular Biology. Helicobacter pylori 1: 293-310, 2001. [] 
.
 
0
-
11. Figueiredo C, Quint WG, Sanna R, Sablon E, Donahue JP, Xu Q, Miller GG, Peek RM, Blaser MJ, van Doorn LJ
Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori. Gene 246: 59-68, 2000. [Article] 
 PMID: 10767527.
 
61
2.5
Senior Author
 
C
IF
1. Ferreira RM, Figueiredo J, Pinto-Ribeiro I, Gullo I, Sgouras DN, Carreto L, Castro P, Santos MA, Carneiro F, Seruca R, Figueiredo C
Activation of Laminin ¿2 by Helicobacter pylori Promotes Invasion and Survival of Gastric Cancer Cells With E-Cadherin Defects. The Journal of infectious diseases 226: 2226-2237, 2022. [Article] 
 doi: 10.1093/infdis/jiac397 PMID: 36173814.
 
0
-
2. Costa CPD, Vieira P, Mendes-Rocha M, Pereira-Marques J, Ferreira RM, Figueiredo C
The Tissue-Associated Microbiota in Colorectal Cancer: A Systematic Review. Cancers 14: ., 2022. [Review] 
 doi: 10.3390/cancers14143385 PMID: 35884445.
 
0
6.6 (*)
3. Marques MS, Costa AC, Osório H, Pinto ML, Relvas S, Dinis-Ribeiro M, Carneiro F, Leite M, Figueiredo C
Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity. Gut microbes 13: 1-21, 2021. [Article] 
 doi: 10.1080/19490976.2021.1921928 PMID: 33970782.
 
5
10.2 (*)
4. Pereira-Marques J, Ferreira RM, Machado JC, Figueiredo C
The influence of the gastric microbiota in gastric cancer development. Best practice & research. Clinical gastroenterology 50-51: 101734, 2021. [Article] 
 doi: 10.1016/j.bpg.2021.101734 PMID: 33975676.
 
4
3.0 (*)
5. Leite M, Marques MS, Melo J, Pinto MT, Cavadas B, Aroso M, Gomez-Lazaro M, Seruca R, Figueiredo C
Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions. Cells 9: ., 2020. [Article] 
 doi: 10.3390/cells9020513 PMID: 32102381.
 
18
4.4 (*)
6. Pinto-Ribeiro I, Ferreira RM, Pereira-Marques J, Pinto V, Macedo G, Carneiro F, Figueiredo C
Evaluation of the Use of Formalin-Fixed and Paraffin-Embedded Archive Gastric Tissues for Microbiota Characterization Using Next-Generation Sequencing. International journal of molecular sciences 21: ., 2020. [Article] 
 doi: 10.3390/ijms21031096 PMID: 32046034.
 
17
4.6 (*)
7. Pereira-Marques J, Hout A, Ferreira RM, Weber M, Pinto-Ribeiro I, van Doorn LJ, Knetsch CW, Figueiredo C
Impact of Host DNA and Sequencing Depth on the Taxonomic Resolution of Whole Metagenome Sequencing for Microbiome Analysis. Frontiers in microbiology 10: 1277, 2019. [Article] 
 doi: 10.3389/fmicb.2019.01277 PMID: 31244801.
 
93
4.2
8. Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota. Gut 67: 226-236, 2018. [Article] 
 doi: 10.1136/gutjnl-2017-314205 PMID: 29102920.
 
370
17.0 (*)
9. Melo J, Marques MS, Fernandes T, Fernandes R, Melo SA, Leite M, Figueiredo C
Characterization of Helicobacter pylori outer membrane vesicles and their effect on gastric epithelial cell-cell junctions Helicobacter 23: ., 2018. [Meeting Abstract] 
.
 
0
4.1 (*)
10. Costa AM, Ferreira RM, Pinto-Ribeiro I, Sougleri IS, Oliveira MJ, Carreto L, Santos MA, Sgouras DN, Carneiro F, Leite M, Figueiredo C
Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways. The Journal of infectious diseases 213: 1767-76, 2016. [Article] 
 doi: 10.1093/infdis/jiw031 PMID: 26802142.
 
40
6.3
11. Ferreira RM, Pinto-Ribeiro I, Wen X, Marcos-Pinto R, Dinis-Ribeiro M, Carneiro F, Figueiredo C
Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion. The Journal of infectious diseases 213: 669-73, 2016. [Article] 
 doi: 10.1093/infdis/jiv467 PMID: 26401027.
 
34
6.3
12. Pinto-Ribeiro I, Ferreira RM, Batalha S, Hlaing T, Wong SI, Carneiro F, Figueiredo C
Helicobacter pylori vacA Genotypes in Chronic Gastritis and Gastric Carcinoma Patients from Macau, China. Toxins 8: 1, 2016. [Article] 
 doi: 10.3390/toxins8050142 PMID: 27164143.
 
17
3.0
13. Ferreira RM, Machado JC, Letley D, Atherton JC, Pardo ML, Gonzalez CA, Carneiro F, Figueiredo C
Correction for Ferreira et al., A Novel Method for Genotyping the Helicobacter pylori vacA Intermediate Region Directly in Gastric Biopsy Specimens. Journal of clinical microbiology 54: 507, 2016. [Correction] 
 doi: 10.1128/JCM.03173-15 PMID: 26822771.
 
0
3.7
14. Ferreira RM, Machado JC, Figueiredo C
Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma. Best practice & research. Clinical gastroenterology 28: 1003-15, 2014. [Article] 
 doi: 10.1016/j.bpg.2014.09.004 PMID: 25439067.
 
44
3.5
15. Bento-Miranda M, Figueiredo C
Helicobacter heilmannii sensu lato: an overview of the infection in humans. World journal of gastroenterology 20: 17779-87, 2014. [Review] 
 doi: 10.3748/wjg.v20.i47.17779 PMID: 25548476.
 
34
2.4
16. Guimarães NM, Azevedo NF, Vieira MJ, Figueiredo C
Water-induced modulation of Helicobacter pylori virulence properties. Memórias do Instituto Oswaldo Cruz 109: 414-9, 2014. [Article] 
 PMID: 25075780.
 
1
1.6
17. Costa AM, Leite M, Seruca R, Figueiredo C
Adherens junctions as targets of microorganisms: A focus on Helicobacter pylori. FEBS letters 587: 259-65, 2013. [Review] 
 doi: 10.1016/j.febslet.2012.12.008 PMID: 23262219.
 
29
3.3
18. Ferreira RM, Machado JC, Leite M, Carneiro F, Figueiredo C
The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma. Histopathology 60: 992-8, 2012. [Article] 
 doi: 10.1111/j.1365-2559.2012.04190.x PMID: 22348604.
 
47
2.9
19. Ferreira RM, Machado JC, Letley D, Atherton JC, Pardo ML, Gonzalez CA, Carneiro F, Figueiredo C
A Novel Method for Genotyping the Helicobacter pylori vacA Intermediate Region Directly in Gastric Biopsy Specimens. Journal of clinical microbiology 50: 3983-9, 2012. [Article] 
 doi: 10.1128/JCM.02087-12 PMID: 23035185.
 
36
4.1
20. Leite M, Figueiredo C
A method for short-term culture of human gastric epithelial cells to study the effects of Helicobacter pylori. Methods in molecular biology (Clifton, N.J.) 921: 61-8, 2012. [] 
 doi: 10.1007/978-1-62703-005-2_9 PMID: 23015492.
 
0
-
21. Vilarinho S, Guimarães NM, Ferreira RM, Gomes B, Wen X, Vieira MJ, Carneiro F, Godinho T, Figueiredo C
Helicobacter pylori colonization of the adenotonsillar tissue: fact or fiction? International journal of pediatric otorhinolaryngology 74: 807-11, 2010. [Article] 
 doi: 10.1016/j.ijporl.2010.04.007 PMID: 20452684.
 
25
1.1
22. Oliveira MJ, Costa AM, Costa AC, Ferreira RM, Sampaio P, Machado JC, Seruca R, Mareel M, Figueiredo C
CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype. The Journal of infectious diseases 200: 745-55, 2009. [Article; Proceedings Paper] 
 doi: 10.1086/604727 PMID: 19604117.
 
78
5.9
23. Costa AC, Pinto ML, Costa AM, Leite M, Ferreira RM, Oliveira MJ, Atherton JC, Mareel M, Figueiredo C
AGS Cells Expressing E-cadherin Establish Tight Junctions and Constitute a Useful Model for Studying H-pylori Infection Helicobacter 14: 336-336, 2009. [Meeting Abstract] 
.
 
1
2.9
24. Ferreira RM, Letley D, Carneiro F, Atherton JC, Figueiredo C
H. pylori vacA Intermediate Region i1 Strains are Associated with More Severe Histologic Features of Chronic Gastritis and Increased Gastric Carcinoma Risk in Portugal Helicobacter 14: 377-377, 2009. [Meeting Abstract] 
.
 
0
2.9
25. Vilarinho S, Ferreira RM, Guimaraes N, Gomes B, Xiaogang W, Oliveira F, Freitas D, Rodrigues B, Atraca E, Pereira G, Marcal N, Carneiro F, Marques A, Godinho T, Figueiredo C
H. pylori Colonization of the Adenotonsillar Tissue: Fact or Fiction? Helicobacter 14: 364-365, 2009. [Meeting Abstract] 
.
 
0
2.9
26. Vilarinho S, Figueiredo C
H. pylori Colonization of the Adenotonsillar Tissue: A Literature Review Helicobacter 14: 353-353, 2009. [Meeting Abstract] 
.
 
0
2.9
27. Ferreira RM, Machado JC, Carneiro F, Figueiredo C
The Number of H. pylori CagA EPIYA C Tyrosine Phosphorylation Motifs is Associated with Histologic Features of Chronic Gastritis Helicobacter 14: 336-337, 2009. [Meeting Abstract] 
.
 
0
2.9
28. Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, Machado JC, Carneiro F, Seruca R, Mareel M, Leroy A, Figueiredo C
Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner. The Journal of biological chemistry 281: 34888-96, 2006. [Article] 
 doi: 10.1074/jbc.M607067200 PMID: 16990273.
 
82
5.8
29. Figueiredo C, Machado JC
Re: Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma Journal of the National Cancer Institute 95: 760-761, 2003. [Letter] 
.
 
0
13.8
30. Figueiredo C
Molecular and Cellular Biology. Helicobacter pylori 1: 293-310, 2001. [] 
.
 
0
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@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
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